The Wanderers will now take on Melbourne Victory on Wednesday 16 February 2022 at CommBank Stadium.
The fixture change from Central Coast Mariners to Melbourne Victory has been made due to Melbourne Victory now qualifying for the AFC Champions League preliminary rounds.
| Date | Home Team | Away Team | KO Time (AEDT) | KO Time (Local) | KO Time (UTC) | Venue |
| Wednesday 16 February 2022 | Western Sydney Wanderers FC | Melbourne Victory | 7:55pm | 7:55pm | 8:55pm | CommBank Stadium |
